Visualization of aberrant perinuclear microtubule aster organization by microtubule-destabilizing agents.
نویسندگان
چکیده
To analyze aberrant spindle formation by microtubule-targeting drugs, live cell imaging was performed using multi-fluorescent human MDA-MB-435 cells in which several spindle components were visualized. Time-lapse images revealed that nocodazole and vinblastine induced additional perinuclear asters at the onset of mitosis. These results imply that these drugs stimulate the microtubule-organizing activity, despite their microtubule-destabilizing properties.
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ورودعنوان ژورنال:
- Bioscience, biotechnology, and biochemistry
دوره 73 5 شماره
صفحات -
تاریخ انتشار 2009